Neuropathology
Chief: Dr. Taratuto, Ana Lía
Launching pioneering techniques in the field of pathology studies of nervous system diseases, the Neuropathology service at FLENI offers immunocytochemistry, computer-assisted imaging, tumor kinetics analysis and ultrastructural studies and molecular biology.
The Neuropathology team performs collaborative studies and research work with national and international institutions.
The Neuropathology service operates within a network of members of the Argentine Society of Neurology and Pathology for Neuropathological Studies and Molecular Biology and the National Registry of Transmissible Human Spongiform Encephalopathies.
1. Tumors of the Central and Peripheral Nervous System
2. Infectious Pathology of the CNS
3. Demyelinating Pathology
4. Vascular Pathology
5. Epilepsy Pathology
6. Peripheral Nerves Pathology
7. Muscle Pathology
8. Neurodegenerative Pathology
9. Applied Research
1. Tumors of the Central and Peripheral Nervous System
• Diagnostic open intrasurgical, stereotactic and deferred biopsy.
• Cellular Kynetics, Immunohistochemistry and Imaging Analysis.
• Flow Cytometry (lymphomas).
• Fluorescent In Situ Hybridization (FISH).
• Molecular biology techniques applied to chemotherapy resistant p53 mutations.
• Detection of target molecules that provide a possible rational basis to define complementary therapies.
• The Neuropathology Lab team is internationally reputed. Since 1990 the Lab is contributing to the Classification of CNS Tumors made by the World Health Organization and it is a member of the Editorial Board of the book "Genetics and Pathology of Central Nervous System Tumors".
2. Infectious Pathology of the CNS
• Diagnostic open intrasurgical, stereotactic and deferred biopsy (viral, bacterial, parasitary and by prions) Immunomarking for viral antigenes.
• In Situ Hybridization (JC etc)
• In Situ PCR for viral DNA. The members of the Neuropathology Laboratory have international reputation in the this field.
3. Demyelinating Pathology
Diagnostic open intrasurgical, stereotactic and deferred biopsy.
4. Vascular Pathology
Histopathological diagnosis of cerebrovascular pathology (carotid endarterectomy) to examine morphological and inflammatory aspects.
5. Epilepsy Pathology
Diagnostic open intrasurgical and deferred biopsy. Analysis of hippocampal and tumoral neocortical or dysmorphical lesions associated to long-dating epilepsy. Molecules related to chemoresistance.
6. Pathology of Peripheral Nerves
Sural nerve biopsy for peripheral neuromuscular pathology. Computer-based imaging analysis to count strands Detection of immunocomplex in endoneuro. Detection of duplications, deletions and point mutations in gene PMP22 for 3 exons of PMP 22 in the biopsy of the sural nerve or lymphocytes.
7. Muscle Pathology
Histological, histochemical, immunohistochemical techniques. Immunemarking in Congenital Muscle Dystrophy, Duchenne and Becker Dystrophy, Limb and Girdle Distrophy.
8. Neurodegenerative Pathology
Neuropathological Diagnosis. Detection of CAG repeats expansions in genes associated to neurodegenerative disorders (HD, SCA1, SCA2, SCA3, SCA6, SMBA, DRPLA).
9. Applied Research
SUBSIDIES
• French Association Against Myopaties
Applied research – Congenital Muscular Dystrophia and Limb Girdle Dystrophia
• Secretariat of Science and Techniques
Transmissible Spongiform Encephalopathies
Molecular Biology Fellow
Medical Staff
Dr. Taratuto Ana Lía (Chief)
Dr. Sevlever Gustavo
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